New finding


Can the inevitable age-related decrement in motor unit number and stability be out run?

Aging is associated with reduced muscle mass and strength. This loss of muscle mass has been termed sarcopenia, meaning “poverty of flesh”.  The loss of muscle mass itself is insufficient to account for strength and power decrements during senescence, which has led to the introduction of the term ‘dynapenia’ to denote […]


Physiological profile of “fallers” with multiple sclerosis

Falls are common among people with multiple sclerosis (MS).  Many clinical tests such as the Berg Balance Scale and the Timed Up and Go or laboratory-based assessments such as posturography involving moving force-plates, have been used to estimate fall risks in MS.  But, these tests are limited to measures of functional balance, […]


Repetitive activity, fatigue and human motoneurones

Exercise induced muscle fatigue is a common experience for healthy people. It involves multiple changes in the nervous system such as changes at the spinal and supraspinal level (central fatigue) and changes in the muscle itself (peripheral fatigue). During a fatiguing maximal effort, the ability of the nervous system to […]


Can we stop older people from falling if we teach them how to step? 2

Balance exercise programs are an effective way to prevent falls in older people. Exercises are mostly focused on controlling the center of mass while reducing the base of support, for example by standing on one leg. Balance control however, also requires adaptive responses that would require a person to either […]


Motor unit remodelling in the aged human vastus lateralis

A progressive reduction in limb muscle mass is characteristic of advancing age, usually referred to as sarcopenia (Rosenberg, 1997). This loss of muscle mass and strength is likely to contribute to the general loss of mobility and risk of falling, a major concern for the elderly. These problems have been […]


Do fitter people experience less pain?

Regular exercise is well demonstrated to relieve pain in people with chronic pain (Busch et al, 2007) but exactly how exercise helps is not known. A growing body of evidence shows people with chronic pain who are fitter and more physically active experience less pain. Similar associations are apparent in […]


The use and abuse of brain stimulation 2

Brain zapping, or non-invasive brain stimulation, in all its forms, has hit the mainstream.  You can even watch a YouTube video about how to build your very own not-approved-for-human-use transcranial magnetic stimulation machine!  Light-heartedness aside, the therapeutic benefits of brain stimulation are regularly highlighted in the news, and the number […]


Even motoneurons need a break! 4

Motoneurons are the final common pathway for every movement and muscle contraction. Located in the spinal cord, these neurons constantly receive and integrate thousands of tiny electrical signals from various parts of the central and peripheral nervous system. The end result: an action potential that travels down their axon and […]